Neuralstem (NASDAQ:CUR) and Regenxbio (NASDAQ:RGNX) are both small-cap medical companies, but which is the better investment? We will contrast the two companies based on the strength of their institutional ownership, valuation, analyst recommendations, profitability, earnings, dividends and risk.

Volatility and Risk

Neuralstem has a beta of 2.66, meaning that its stock price is 166% more volatile than the S&P 500. Comparatively, Regenxbio has a beta of 0.37, meaning that its stock price is 63% less volatile than the S&P 500.

Earnings and Valuation

This table compares Neuralstem and Regenxbio’s top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Neuralstem $260,000.00 33.10 -$4.93 million N/A N/A
Regenxbio $218.51 million 7.35 $99.94 million $2.38 18.43

Regenxbio has higher revenue and earnings than Neuralstem.

Analyst Recommendations

This is a summary of current ratings for Neuralstem and Regenxbio, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Neuralstem 0 0 0 0 N/A
Regenxbio 1 1 4 1 2.71

Regenxbio has a consensus price target of $81.68, suggesting a potential upside of 86.23%. Given Regenxbio’s higher probable upside, analysts clearly believe Regenxbio is more favorable than Neuralstem.


This table compares Neuralstem and Regenxbio’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Neuralstem -1,879.39% -84.71% -54.45%
Regenxbio -41.99% -9.90% -9.35%

Insider & Institutional Ownership

15.4% of Neuralstem shares are held by institutional investors. Comparatively, 82.6% of Regenxbio shares are held by institutional investors. 30.1% of Neuralstem shares are held by insiders. Comparatively, 13.8% of Regenxbio shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.


Regenxbio beats Neuralstem on 9 of the 12 factors compared between the two stocks.

About Neuralstem

Neuralstem, Inc., a clinical stage biopharmaceutical company, focuses on the research and development of nervous system therapies based on its proprietary human neuronal stem cells and small molecule compounds. The company’s stem cell based technology enables the isolation and expansion of human neural stem cells from various areas of the developing human brain and spinal cord enabling the generation of physiologically relevant human neurons of various types. Its lead product candidate is NSI-189, a chemical entity, which has been completed Phase II clinical trial for the treatment of major depressive disorder, as well as is in preclinical study for the MCAO stroke, type 1 and 2 diabetes related neuropathy, irradiation-induced cognition, long-term potentiation enhancement, and angelman syndrome. The company also develops NSI-566, which has completed Phase II clinical trial for treating amyotrophic lateral sclerosis disease, as well as is in Phase I clinical trials for the treatment of chronic spinal cord injury and motor deficits due to ischemic stroke. Neuralstem, Inc. was founded in 1996 and is headquartered in Germantown, Maryland.

About Regenxbio

REGENXBIO Inc., a clinical-stage biotechnology company, provides gene therapy product candidates to deliver genes to cells to address genetic defects or to enable cells in the body to produce therapeutic proteins or antibodies that are intended to impact disease. Its gene therapy product candidates are based on NAV Technology Platform, a proprietary adeno-associated virus (AAV) gene delivery platform. The company’s lead product candidate is RGX-314, which is in Phase I/IIa clinical trials for the treatment of wet age-related macular degeneration. It is also developing RGX-121 that is in Phase I/II clinical trials to treat mucopolysaccharidosis type II; RGX-111 for treating mucopolysaccharidosis type I; RGX-181 for the treatment of late infantile neuronal ceroid lipofuscinosis type II disease; and RGX-501, which is in Phase I/II clinical trials to treat homozygous familial hypercholesterolemia. REGENXBIO Inc. also licenses its NAV Technology Platform to other biotechnology and pharmaceutical companies. The company was formerly known as REGENX Biosciences, LLC and changed its name to REGENXBIO Inc. in September 2014. REGENXBIO Inc. was founded in 2008 and is headquartered in Rockville, Maryland.

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